Differences ...

How would an interaction between a person in 2-d coordinate system and a person in 3-d coordinate system be like ?

Obviously frequent fights rather than the curiosity to know what's going on and how things work in the other world ...

(Idea from Carl Sagan's DVD "Cosmos", where he tells that a person in 2-d space knows ONLY length and breadth and no height, and the notion of height is weird to him)